01/02/2017 · Sorafenib may improve progression-free survival PFS and overall survival OS of advanced hepatocellular carcinoma HCC. However, the survival benefit is short lived and survivals after progressive disease PD have not been well characterized. This study aimed to evaluate the survival predictors. Both median survival and time to progression showed 3-month improvements; however, there was no significant difference in median time to symptomatic progression p=0.77. There was no difference in quality of life measures, possibly attributable to toxicity of sorafenib or symptoms related to underlying progression of liver disease.
05/09/2018 · The combination of the MEK inhibitor refametinib and sorafenib Nexavar improved overall survival OS and overall response rate ORR compared with refametinib alone in patients with RAS-mutated hepatocellular carcinoma HCC, according to an analysis of. 20/09/2019 · Maria Varela, of the Liver Unit at the Hospital Universitario Central de Asturias in Oviedo, Spain, discusses the findings from an analysis comparing the safety and efficacy of sorafenib Nexavar versus regorafenib Stivarga in a real-life cohort of patients with hepatocellular carcinoma HCC following progression. 15/03/2017 · Sorafenib Nexavar® is currently the only systemic agent approved for use in hepatocellular carcinoma HCC. Its approval was based on the results of the pivotal SHARP and Sorafenib Asia-Pacific AP trials in Child-Pugh CP class A patients with advanced HCC, which showed significantly longer median overall survival OS and time to.
Combining sorafenib Nexavar with internal radiation therapy or transarterial chemoembolization did not improve overall survival for people with liver cancer, but it did appear to help certain groups of patients, according to research presented at the 2018 International Liver Congress this month in Paris. Patients with HCC who underwent hepatectomy and were pathologically diagnosed as MVI at the research center between January 2009 and December 2016 were retrospectively analyzed. Patients were divided into sorafenib group and control group according to whether or not sorafenib Nexavar® was taken after surgery. Background & Aims. Sorafenib is the recommended treatment for patients with advanced hepatocellular carcinoma HCC. We aimed to compare the efficacy and safety of a combination of sorafenib and selective internal radiation therapy SIRT – with yttrium-90 90 Y resin microspheres – to sorafenib alone in patients with advanced HCC. Sorafenib is an inhibitor of several serine and threonine kinases, such as RAF, and tyrosine kinases, including VEGFRs. Sorafenib has been shown to block ERK activity and proliferation of flt-3–mutant acute myeloid leukemia cells 14, 15 and reduce ERK phosphorylation of endothelial progenitor cells from patients with HCC.
01/06/2019 · Objective Sorafenib is the standard systemic therapy for advanced hepatocellular carcinoma HCC. Survival benefits of resection/local ablation for early HCC are compromised by 70% 5-year recurrence rates. The phase 3 STORM trial comparing sorafenib with placebo as adjuvant treatment did not achieve its primary endpoint of improving recurrence. Differences in survival outcomes have been reported in systemic HCC trials, possibly related to different etiological responses or as a result of disease-stage migration related to practice differences. 3 Aside from the sorafenib and regorafenib phase III trials, the ramucirumab phase III second-line trial similarly showed regional differences. Sorafenib ha ridotto dimensione della lesione bersaglio nel 73% dei pazienti, rispetto al 27% nel braccio placebo. Di nota, il restringimento del tumore con sorafenib in pazienti sintomatici era spesso sufficiente ad alleviare i sintomi, il dottor Brose ha detto. Conclusions: Survival in patients with HCC has improved since 2008, which is limited to early stage HCC. Survival of advanced stage HCC patients is extremely poor and has not shown any significant improvement since the approval of sorafenib, emphasizing the need for better therapeutic options. Background & Aims. Sorafenib is the standard of care for advanced hepatocellular carcinoma HCC. Combining sorafenib with another treatment, to improve overall survival OS within an acceptable safety profile, might be the next step forward in the management of patients with advanced HCC.
19/12/2017 · Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma HCC. Predicting this drug’s survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that serum cytokines levels could. We compared advanced stage patients with HCC American Joint Committee on Cancer stage III/IV who received sorafenib within 6 months of diagnosis and were otherwise untreated to advanced stage patients with HCC who received no therapy control. We performed univariate and multivariate analyses to identify predictors of survival.
Sorafenib Nexavar® is currently the only systemic agent approved for use in hepatocellular carcinoma HCC. Its approval was based on the results of the pivotal SHARP and Sorafenib Asia-Pacific AP trials in Child-Pugh CP class A patients with advanced HCC, which showed significantly longer median overall survival OS and time to. 18/03/2018 · In a study of 90 HCC patients with macroscopic portal vein invasion, the median overall survival among those treated with TACE-RT was 55 weeks versus 43 weeks in those treated with sorafenib hazard ratio 0.61, 95% CI 0.38-0.98, P=0.04, reported Young-Suk Lim, MD, PhD, of Asan Medical Center in Seoul, South Korea, and colleagues.
epatocellulare hepatocellular carcinoma, HCC e del carcinoma a cellule renali renal cell carcinoma, RCC avanzato, la dose di Nexavar deve essere ridotta a due compresse da 200 mg di sorafenib una volta al giorno vedere paragrafo 4.4. 11/12/2019 · The phase III CheckMate 459 trial NCT02576509 demonstrated a clear trend towards improvement in overall survival OS with the treatment of nivolumab Opdivo versus sorafenib Nexavar in treatment-naïve patients with unresectable hepatocellular carcinoma HCC. However, the study failed to meet. CONCLUSION: Use of RFA of both HCC and MPVTT plus sorafenib significantly increases 3-year survival compared to sorafenib alone. Related: Liver Cancer Sorafenib Nexavar Garuti F, Camelli V, Spinardi L, et al. Osteonecrosis of the jaw during sorafenib therapy for hepatocellular carcinoma. 28/10/2019 · Sorafenib Nexavar plus doxorubicin Adriamycin, Rubex failed to improve survival in patients with advanced hepatocellular carcinoma HCC compared with sorafenib alone in the first-line setting, according to the results of the randomized phase 3 CALGB 80802 clinical trial.
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